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Digsby – one stop shop for all your instant messaging, email notification and social network needs.
GreatNews – a portable RSS Feed Reader, for those that do not want Google Reader to know what they’ve been reading.
Media Player Classic – a portable, tiny and unobtrusive player for all audio, video and streaming formats.
Miro – offline television viewing, including video podcasts, YouTube HD and more. It’s the best thing after TiVo.
POP Peeper – a Portable multi-account email notifier supporting POP3 / IMAP / Gmail / Yahoo / MSN and more.
Screen Loupe 2000 – magnify a specified area of your computer screen up to 8 times larger.
TeraCopy – transfer files/folders faster over LAN or between two physical hard drives.

Comments:
1. Softwares listed in alphabetical order – each one tested under Windows XP.
2. The term ‘portable’ means the software can run from any USB flash drive / DiskOnKey / ThumbDrive.
3. Make sure you also check out my original 2008 post titled 10 Freewares I Swear By But You Have Never Heard Of.

…listed in Alphabetical order – each one tested under Windows XP:

CCleaner	Removes unused files and cleans traces of your online activities
CutePDF Writer	Easily convert any document to PDF format
Easy Video Splitter	Automatically or manually split large AVI, DivX, MPEG, WMV and ASF
JFileRecovery	Copy files from damaged hard drives, CDs, DVDs and Flash media
MailWasher	Automatically block email spam before using your regular email program
QuickSearcher	Search for a text string within multiple directories and files
RoboForm2Go	Memorizes your passwords on your USB key and automatically logs you into online accounts
SizeMe	Assists backing up files by filling up each disc as much as possible
UltraVNC	Connect to a remote PC and work on it or transfer files (similar to pcAnywhere)
WindizUpdate	Keep your Windows up-to-date without using Microsoft Update
Honorobale mention:
ShowIP	Shows and logs the local IP and the WAN IP in the system tray